WS04 – NRP in donation after circulatory death (DCD)

Normothermic regional perfusion (NRP) in donation after circulatory death (DCD) has been introduced in clinical practice in some of the European countries with active DCD programmes. In contrast to direct organ procurement (DOP), NRP restores the circulation in the abdominal or thoraco-abdominal cavity and has been associated with improved organ utilisation and reduced post-transplant complications.

This workflow aims to provide an evidence based answer to the following question: Should NRP become standard of care in DCD donation?

The available evidence with regard heart, lung, kidney, pancreas, and liver transplantation for the following topics will be critically appraised:

  • Safety of NRP as a procedure (i.e. risk of organ loss)
  • Organ utilization rates after NRP compared to DOP
  • Post-transplant outcomes (both early and late) after NRP compared to DOP
  • Organ viability criteria during NRP described in literature

Learning objectives
: This comprehensive overview of the NRP-process is directed at both the starter and the specialist. At the end of the TLJ2.0 you will have a deep understanding of what normothermic regional perfusion is and how you can set up such a programme in your own centre. You will understand both ethical and technical pitfalls of the technique and be able to identify what the value of the technique is and where further development and research in the field is needed. The Workstream covers not only basic principles, it also provides an overview of the different techniques and the logistical process required for successful NRP. Furthermore, it provides a state-of-the-art overview of outcomes achieved with this technique for all solid organs and lists currently used viability criteria by which NRP-organs are selected for transplantation

Target group: Procurement surgeons, transplant surgeons, transplant coordinators, donor coordinators, organ perfusion specialists, physicians and nurses in charge of donor management, transplant nurses, organ allocation officers, physicians taking care of organ recipients

Leader: Ina Jochmans

Group members: Amelia Hessheimer (Spain), Arne Neyrinck (Belgium), John Dark (UK), Chris Watson (UK), Diederik Kimenai (The Netherlands), David Paredes Zapata (Spain).

Forum moderator: Maria Irene Bellini

Programme Activities:

WS04 Report (20 min) + Live Q&A (10 min) 15 November, 14:15-15:15 CET

Focus on topic WS04 (15 min) + Live Q&A (15 min) 15 November, 16:45-17:45 CET