PREPARATORY WEBINARS

Description and Rationale:
To increase the knowledge on the concept of ICOD and to highlight the most critical issues to ICOD pathways in hospitals to show the outcomes of ICOD application in some clinical realities.

Main Topics:

Practices in Europe, donation as a part of the End of Life care Pathway, Prognosis of the devastating brain injure and evolution to BD, approaching the family, building an organ donation process on the uncertainty, outcomes, ICOD pros/cons

Target Audience:
Transplant coordinators, transplant surgeons, neuro intensivists, intensivists, hospital medical directors, ER

Confirmed Panellists:
Giuseppe Feltrin
Angela Kotsopoulos
Teresa Pont

Description and Rationale:
To address the complexity of paediatric transplant recipient and the challenges it brings to transplantation, particularly in patients that need more than one solid organ transplant. The webinar will expand on medical and surgical challenges in patients undergoing simultaneous organ transplantation, as well as challenges related to the transplantation of children with metabolic conditions

Main Topics:
The medical and surgical profile of solid organ transplant recipients in the 21st century; combined liver and kidney transplantation and transplantation in children with metabolic conditions

Target Audience:
All medical professionals who are involved in renal, hepatic, pancreatic, heart and lung transplantation including nurses, coordinators, medical students

Confirmed Pannelists:
Jelena Stojanovic,
Chaya Kelgeri,
Nizam Mamode

Description and Rationale:

In the first successful webinar that was held on July 6th 2020 (https://youtu.be/Eed4BxANPls), we discussed the current status of xenotransplantation. Why xenotransplantation is promising, when we anticipate that clinical trials will become reality, and what are the health authority regulatory hurdles.

In this second webinar of the series, the tremendous progress achieved by xenotransplantation will be used as paradigm for initiating discussions on other futuristic transplants: 3D printed organs, regenerated organs, lab-grown organs etc. We will discuss how the right clinical trials could be designed and how to make disruptive technologies economically healthy and logistically feasible.

We will also address the societal impact of these futuristic transplants, the risks for misperception and the communication strategies to increase awareness and acceptance of such futuristic transplants with patients and society at large.

Finally, we will learn how the European Commission and European environment are supporting these innovations and keep Europe on the forefront of this field.

In a final focus session that will be held during the TLJ 2.0 online experience, we will take more time to address the ethical issues related to futuristic transplants. From the patient viewpoint on selection and access to transplantation, but e.g. also from animal rights perspective.

For additional information on the activities and the aim of this workstream (ws01) please refer to: http://tlj-esot.org/programme/ws01

Main Topics:

• Prepping the kidney transplants of the future: lessons from xenotransplantation for other futuristic transplants
• Cross species kidney transplantation- thoughts on patient selection and trial
• Are futuristic transplants acceptable by patients and society?
• The future of transplantation in the European Research ecosystem

Confirmed Panellists:

Maria Irene Bellini
Kevin Fowler
Martin Hoogduijn
Rainer Oberbauer
Anna-Pia Papageorgiou

Description and Rationale:
Ischemia reperfusion injury (IRI) limits transplant survival and availability of organs. In this webinar, participants will learn about changes induced by IRI on the level of gene expression for a more basic understanding of the matter. In the second talk, participants will learn about possibilities of ex vivo perfusion and its impact on allograft survival and clinical outcome. Focus is the translational aspect of this topic from the epigenetic mechanisms underlying IRI to ex vivo liver perfusion. After this webinar, participants should be able to understand the regulation of ischemia reperfusion injury at the level of epigenetics and also know about the latest findings in ex vivo liver perfusion for the prevention of IRI

Main Topics:

• Ischemia reperfusion injury
• Regeneration
• Ex vivo perfusion

Target audience:
All fields involved in health care and research with affiliation in transplantation. I.e. Transplant Scientists, Transplant Surgeons and Clinicians, Researchers in transplant related fields (Immunology, Stem cells, Regenerative Medicine). Physicians, Nurses, Coordinators, Pharmacists with Involvement or interest in the field of transplantation, Students working in or interested in the field of transplantation immunology, Patients interested in the newest research

Confirmed panellists:
Philip Dutkowski,
Jan Lindeman

Description and Rationale:
Dealing with the uncertainty associated with transplantation has recently been identified as a key priority for those awaiting a transplant, those who have received a transplant and for transplant professionals. This webinar will consider the issues surrounding uncertainty whilst on a transplant waiting list. The first part of the webinar will include talks by a transplant professional and a transplant recipient, presenting their perspectives on waitlist-related uncertainty. The discussion will then be opened to the audience for questions and answers.

Learning Objectives:

• To understand uncertainty whilst waiting for an organ, from the perspective of both patients and transplant professionals
• To explore specific issues related to being on the waiting list and how these can be addressed
• To discuss experiences and management strategies for patients to use whilst waiting

Target Audience:
Physicians, transplant donor coordinators, nurses, allied healthcare professionals, professionals focusing on the ethical, legal and psychosocial aspects of organ transplantation, representatives of patient organizations, individual patients and their significant others. 

Confirmed Panellists:
Pisana Ferrari, Italy
Fiona Loud, UK
Hannah Maple, UK
Irena Milaniak, Poland

Description and Rationale:
Tolerance is still considered to be the holy grail in transplantation. Although, short time survival rates have dramatically improved in all fields of transplantation, long term survival is still limited and patients suffer from side effects of chronic immunosuppression. In this webinar, patients will learn about new approaches and specific problems in VCA, the role of regulatory CD8+ T cells in tolerance induction and the implications for tolerance approaches as well as the limits of VCA and novel approaches coming from regenerative medicine. After this webinar participants should have a fundamental knowledge about state of the art in VCA, as well as its limitations and latest developments in regenerative medicine augmenting this exciting field. Moreover participants will learn about the role of regulatory CD8+ T cells and their role in tolerance and transplantation.

Main Topics:

• Allograft Tolerance
• Regulatory T cells
• Vascularized Composite
• Allotransplantation

Target audience:
All fields involved in health care and research with affiliation in transplantation. I.e, Transplant Scientists, Transplant Surgeons and Clinicians, Researchers in transplant related fields (Immunology, Stem cells, Regenerative Medicine), Physicians, Nurses, Coordinators, Pharmacists with Involvement or interest in the field of transplantation, Students working in or interested in the field of transplantation immunology, Patients interested in the newest research.

Confirmed panellists:
Carole Guillonneau,
Gerald Brandacher,
Fadi Issa

Description and Rationale:
Dealing with the uncertainty associated with transplantation has recently been identified as a key priority for those awaiting a transplant, those who have received a transplant and for transplant professionals. The aim of this webinar is to twofold: on the one hand, we wish to get insight into the uncertainty of a transplant professional when offering a post mortem donor organ to his/her patient on the waiting list; on the other hand, we wish to get insight into the uncertainty of the transplant patient in accepting the organ offer. From both perspectives the organ donor is unknown, which causes all kinds of uncertainty. Together, the transplant professional and the patient need to make the right decision.

Learning Objectives:

• To understand the recipient’s concerns and uncertainty when deciding whether to accept an organ or not (“Was the donor healthy enough to be sure that there are no risks for me after transplantation? Did the donor have a healthy lifestyle?”).
• To understand the transplant professional’s concerns and uncertainty when accepting an organ offer (“Can I be sure that this organ carries no risks of infectious disease or neoplasia transmission after transplantation for my patient? Is this the best offer my patient can get?”).
• To learn from the uncertainty of both patients and transplant professionals and to explore possible pathways to shared decision-making.

Target Audience:
Physicians, transplant donor coordinators, nurses, allied healthcare professionals, professionals focusing on the ethical, legal and psychosocial aspects of organ transplantation, representatives of patient organizations, individual patients and their significant others. 

Description and Rationale:
The session will aim at asking questions relevant to heart and lung transplantation and presenting PROs & CONs. In this session, we will discuss thoracic organs procurement with machine perfusion.

Main Topics:

• Cardiothoracic organs transplantation
• Machine perfusion

Target Audience:
Cardiologists, Cardiac Surgeons, Pneumologists, Lung Transplant Surgeons

Confirmed Panellists:
Gregor Warnecke, Germany
Bruno Meiser, Germany

Description and Rationale:
Currently available diagnostic tools perform poorly if it comes to early stages of alloimmunity leading to graft rejection and subsequent graft loss. These shortcomings have been motivation for exploring new diagnostic biomarkers, especially metabolic biomarkers as patients would eventually benefit from an improved post-transplant management and of course a deeper understanding on how metabolics shape the immune response. After attending this webinar, participants will be able to understand the newest findings on how the innate immunity and metabolisms affect transplant survival and know about the importance of metabolic biomarkers in renal transplantation.

Target Audience:
All fields involved in health care and research with affiliation in transplantation i.e: Transplant Scientists, Transplant Surgeons and Clinicians, Researchers in transplant related fields (Immunology, Stem cells, Regenerative Medicine), Physicians, Nurses, Coordinators, Pharmacists with Involvement or interest in the field of transplantation, Students working in or interested in the field of transplantation immunology, Patients interested in the newest research.

Confirmed Panellists:
Rikke Norregaard,
Raphael Duivenvoorden,
Ping Chih Ho